Gene SOCS1 map

Identifiers
HUGO:SOCS1

Maps_Modules
 MACROPHAGE  map
 DENDRITIC_CELL  map
MODULE:INPUT_ACTIVATORS
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
CASCADE:IL13
CASCADE:IFNG
CASCADE:IL4

References
PMID:12433365, PMID:10485906
INFG induces SOCS1 expression in macrophages.
PMID:10820262
Probably IFNG induces SOCS1 expressiov via IRF1 upregulation downstream of STAT1
PMID:21097505
IL-13 upregulates expression of SOCS1.
PMID:14764699
SOCS1 and SOCS3 are upregulated in mature DC. SOCS2 in immature DC.
SOCS1 and SOCS2 expression is induced by IL4 signaling, and SOCS3 expression is upregulated more by GM-CSF (CSF2).

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gSOCS1@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gSOCS1@INNATE_IMMUNE_CELL_Cytosol map → map rSOCS1@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: