Identifiers
HUGO:IL1A

Maps_Modules
 MACROPHAGE 
 MAST_CELL 
MODULE:EFFECTOR_INHIBITION
MODULE:TUMOR_GROWTH
MODULE:ANGIOGENIC_FACTORS
CASCADE:TLR2_4
CASCADE:IL15

References
PMID:17043764
IL1 signaling has both antitumor effect (low dose of IL B and menbran associated IL1A) and protumor effect (high dose of IL1) in tumor microevironment,
PMID:12598651
Microenvironmental IL-1 beta and, to a lesser extent, IL-1 alpha are required for in vivo angiogenesis and invasiveness of different tumor cells.
PMID:17404308
CSF1 downregulates TNF, IL-23p19, IL-12p40 expression probably via induction of acomulation of p50 homodimer and inhibition of p65/p50 NF-kB signaling.
PMID:18633355
TAM express many pro-angiogenic and angiogenesis-modulating factors in vitro, such as VEGF, basic fibroblast growth factor (bFGF, also known as FGF2), tumour necrosis factor (TNF), interleukin 1 (IL1), chemokine (C-X-C motif) ligand 8 (CXCL8; also known as IL8), cyclooxygenase 2 (COX2, also known as PTGS2), plasminogen activator, urokinase (uPA, also known as PLAU), platelet derived growth factor beta.
PMID:16410834
T-bet upregulates the production of proinflammatory cytokine IL-1α and chemokines macrophage inflammatory protein-1α (MIP-1α) and downregulatesthymus- and activation-related chemokine (TARC) by DCs.
PMID:15099563
Mast cells produce cytokines TNF-a, TGF-b, IFN-a, IL-1a, IL-1b, IL-5, IL-6,
IL-13, IL-16, IL-18

1. IL1A@INNATE_IMMUNE_CELL_Cytosol

1. IL1A@default

1. IL1A@INNATE_IMMUNE_CELL_Cytosol → IL1A@default
2. IL1A@default → ANGIOGENESIS@default
3. rIL1A@INNATE_IMMUNE_CELL_Cytosol → IL1A@INNATE_IMMUNE_CELL_Cytosol