Gene HIF2A* map

Identifiers
HUGO:EPAS1

Maps_Modules
 MACROPHAGE  map
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:MIRNA_TF_IMMUNOSUPPRESSIVE
CASCADE:IL4
CASCADE:IL13
CASCADE:IFNG

References
PMID:20194441
HIF2a expression is assosiated with M2 phenotype.
PMID:11888900, PMID:20644254
HIF2A induces tumor growth and angiogenesis.
PMID:16127144
HIF-1A and HIF-2A are up-regulated by human macrophages exposed to hypoxia in vitro and by TAMs in hypoxic/necrotic areas of human tumors
PMID:20644254
HIF2a induces macrophage migration via upregulation of CXCR4, FN1 expression and upregulation of M-CSFR protein level.
INFG enhanced the synthesis of HIF-1 mRNA and strongly reduced HIF-2 mRNA synthesis.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gHIF2A*@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gHIF2A*@INNATE_IMMUNE_CELL_Cytosol map → map rHIF2A*@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: