Gene PTGS2 map

Identifiers
HUGO:PTGS2

Maps_Modules
MODULE:EFFECTOR_INHIBITION MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_EXPRESSION MODULE:IMMUNE_SUPPRESSION

References
 MACROPHAGE  map
CASCADE:MIF
CASCADE:TLR2_4
PMID:23390297
MIF inhitits expression of M1 markers such as TNF, IL12p40, COX2, INOS, IRF-5, MHC-II, CD11c, CD80, CD86 and MIF induces expression of M2 markers as IL10, stabilin-1, MRC-1, CD206, CD23
PMID:11668179
CREB, NF-kappa B, and both C/EBP beta and -delta as key factors in coordinately orchestrating transcription from the COX-2 promoter in activated macrophages.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gPTGS2@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gPTGS2@INNATE_IMMUNE_CELL_Cytosol map → map rPTGS2@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: