Identifiers
HUGO:SPI1
Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:MIRNA_TF_IMMUNOSTIMULATORY
References
DENDRITIC_CELL
CASCADE:FLT3LG
PMID:20510871
SPI1 (PU.1) is a critical regulator of both conventional and plasmacytoid DC development. It is directly upregulates Flt3 gene activation.
PMID:16418395
FLT3L induces PU.1 and STAT3 mRNA expression in DC progenitors and downregulates GATA1 mRNA expression. At The same time enforced expression of STAT3 or PU.1 in DC progenitors led to the up-regulation of Flt3 mRNA levels, so there is a positive loop in this signaling. Enforced STAT3 or PU.1 expression instructs progenitors to differentiate into Dcs. Additionaly it induces expression mRNAs of cytokine receptors for G-CSF, M-CSF, and GM-CSF probably downstream of STAT3 ()