Gene IRF8 map

Identifiers
HUGO:IRF8

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:MIRNA_TF_IMMUNOSTIMULATORY

References
 MACROPHAGE  map
 MDSC  map
CASCADE:GSF3
CASCADE:GSF2
PMID:24091328
G-CSF downregulates IRF8 expression via STAT3 and GM-CSF via STAT5. IRF8 inhibition provides immunosuppressive functions of MDSC.
PMID:8133040
In mouse macrophages, priming with IFN-γ drastically up-regulates expression of the transcription factor ICSBP (IRF8)

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gIRF8@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gIRF8@INNATE_IMMUNE_CELL_Cytosol map → map rIRF8@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: