Simple molecule Heparin map
Heparin@TUMOR_CELL_AS_INDUCTOR_Membrane

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:TUMOR_RECOGNTITON MODULE:NK_ACTIVATING_RECEPTORS

References
 NATURAL_KILLER  map
CASCADE:NKP44
CASCADE:NKP30
PMID:23414611, PMID:19196184, PMID:15294952
Heparin is ligand of NKp30, NKp44 and Nkp46. The NCRs initiate tumor targeting by recognition of heparan sulfate on cancer cells. Tumor cells expressing cell surface heparanase or lacking membranal heparan manifest reduced recognition by NKp30 and NKp46 and are lysed to a lesser extent by NK cells.

Heparin@INNATE_IMMUNE_CELL_Cytosol

References
 MAST_CELL  map
PMID:15099563
Mast cells produce heparin, interleukin-8 (IL-8) and vascular
endothelial cell growth factor (VEGF), which induce
neovascularization,

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. Heparin@INNATE_IMMUNE_CELL_Cytosol map
In compartment: TUMOR_CELL_AS_INDUCTOR_Membrane
  1. Heparin@TUMOR_CELL_AS_INDUCTOR_Membrane map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. Heparin@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
    As Catalyser:
    1. CD247:​NKp30*@INNATE_IMMUNE_CELL_Membrane map → map CD247|​pho:​NKp30*@INNATE_IMMUNE_CELL_Membrane map
    2. CD247:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map → map CD247:​CD247|​pho:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map
    3. DAP12*:​NKp44*@INNATE_IMMUNE_CELL_Membrane map → map DAP12*|​pho:​NKp44*@INNATE_IMMUNE_CELL_Membrane map