Identifiers
HUGO:BCAR1

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS

References
 DENDRITIC_CELL 
 NATURAL_KILLER 
CASCADE:INTEGRIN_AVB5
PMID:18835194
Several YxxP motifs for binding of (CrkII) are also present in the scaffold protein BCAR1 (p130CAS).
Association of CrkII with c-Cbl, p130CAS, and C3G was induced by activation of NK cells.

1. BCAR1@INNATE_IMMUNE_CELL_Cytosol

1. BCAR1:​CRK:​DOCK1@INNATE_IMMUNE_CELL_Cytosol
2. (BCAR1|​pho:​CBL|​pho:​CRK:​CRKL:​RAPGEF1)|​active@INNATE_IMMUNE_CELL_Cytosol
3. BCAR1|​pho:​CBL|​pho:​CRKL|​pho:​CRK|​pho:​RAPGEF1@INNATE_IMMUNE_CELL_Cytosol

1. (BCAR1|​pho:​CBL|​pho:​CRK:​CRKL:​RAPGEF1)|​active@INNATE_IMMUNE_CELL_Cytosol → BCAR1|​pho:​CBL|​pho:​CRKL|​pho:​CRK|​pho:​RAPGEF1@INNATE_IMMUNE_CELL_Cytosol
2. BCAR1@INNATE_IMMUNE_CELL_Cytosol + RAPGEF1@INNATE_IMMUNE_CELL_Cytosol + CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol + CRK@INNATE_IMMUNE_CELL_Cytosol + CRKL@INNATE_IMMUNE_CELL_Cytosol → (BCAR1|​pho:​CBL|​pho:​CRK:​CRKL:​RAPGEF1)|​active@INNATE_IMMUNE_CELL_Cytosol
3. BCAR1|​pho:​CBL|​pho:​CRKL|​pho:​CRK|​pho:​RAPGEF1@INNATE_IMMUNE_CELL_Cytosol → RAPGEF1@INNATE_IMMUNE_CELL_Cytosol + BCAR1@INNATE_IMMUNE_CELL_Cytosol + CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol + CRK|​pho@INNATE_IMMUNE_CELL_Cytosol + CRKL|​pho@INNATE_IMMUNE_CELL_Cytosol + CRKL@INNATE_IMMUNE_CELL_Cytosol
4. CRK@INNATE_IMMUNE_CELL_Cytosol + DOCK1@INNATE_IMMUNE_CELL_Cytosol + BCAR1@INNATE_IMMUNE_CELL_Cytosol → BCAR1:​CRK:​DOCK1@INNATE_IMMUNE_CELL_Cytosol

1. GDP:​RAC1_2*@INNATE_IMMUNE_CELL_Cytosol + GTP@INNATE_IMMUNE_CELL_Cytosol → (GTP:​RAC1_2*)|​active@INNATE_IMMUNE_CELL_Cytosol + GDP@INNATE_IMMUNE_CELL_Cytosol
2. GDP:​RAP1A@INNATE_IMMUNE_CELL_Cytosol + GTP@INNATE_IMMUNE_CELL_Cytosol → (GTP:​RAP1A)|​active@INNATE_IMMUNE_CELL_Cytosol + GDP@INNATE_IMMUNE_CELL_Cytosol