Protein B7H6* map

Identifiers
HUGO:NCR3LG1

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:TUMOR_RECOGNTITON MODULE:NK_ACTIVATING_RECEPTORS

References
 NATURAL_KILLER  map
CASCADE:NKP30
PMID:23414611, PMID:19528259, PMID:19528259, PMID:23801635
B7H6 (NCR3LG) is a Nkp30 ligand.It is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3) results in natural killer (NK) cell activation and cytotoxicity.
Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells.

Modifications:
In compartment: TUMOR_CELL_AS_INDUCTOR
  1. B7H6*@TUMOR_CELL_AS_INDUCTOR map
In compartment: TUMOR_CELL_AS_INDUCTOR_Membrane
  1. B7H6*@TUMOR_CELL_AS_INDUCTOR_Membrane map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rB7H6*@TUMOR_CELL_AS_INDUCTOR map → map B7H6*@TUMOR_CELL_AS_INDUCTOR map
    2. B7H6*@TUMOR_CELL_AS_INDUCTOR map → map B7H6*@TUMOR_CELL_AS_INDUCTOR_Membrane map
    As Catalyser:
    1. CD247:​NKp30*@INNATE_IMMUNE_CELL_Membrane map → map CD247|​pho:​NKp30*@INNATE_IMMUNE_CELL_Membrane map