Protein ADAM17 map

Identifiers
HUGO:ADAM17

References
 NATURAL_KILLER  map
PMID:18676862
Tumor-Associated MICA Is shed by ADAM10 and ADAM17 proteases.
ADAM17 is understood to be involved in the processing of tumor necrosis factor alpha (TNF-α) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network. This process, which is also known as 'shedding', involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins (such as pro-TNF-α), and is of known physiological importance.

Modifications:
In compartment: TUMOR_CELL_AS_INDUCTOR
  1. ADAM17@TUMOR_CELL_AS_INDUCTOR map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. TNF@INNATE_IMMUNE_CELL_Cytosol map → map TNF@default map