Protein TNF map

Identifiers
HUGO:TNF

Maps_Modules
 MACROPHAGE  map
 MAST_CELL  map
 MDSC  map
 NEUTROPHIL  map
 DENDRITIC_CELL  map
MODULE:INPUT_ACTIVATORS
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
MODULE:TUMOR_KILLING
MODULE:EFFECTOR_ACTIVATION
MODULE:APOPTOSIS_INDUCING_LIGANDS
MODULE:EXOCYTOSIS_AND_PHAGOCYTOSIS
MODULE:IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION
CASCADE:TGFB
CASCADE:MIF
CASCADE:IL10
CASCADE:KLRG1
CASCADE:FCAR
CASCADE:Fc_gamma_RIII
CASCADE:TLR2_4
CASCADE:IL15
CASCADE:CSF2
CASCADE:CSF1
CASCADE:TNF
CASCADE:IFNG
PMID:19732719 
Inhibition of TGF-ß signaling downregulates Arginase1, CCL5 and CCL2 expression and upregulates TNF, ICAM1,CCL3 expression (mRNA) in tumor neutrophiles (TAN)

References
PMID:21133840
TNF is a pleiotropic cytokine produced by many different types of cells in the body. However, cells of the monocytic lineage—such as macrophages, astroglia, microglia, Langerhans cells, Kupffer cells, and alveolar macrophages—are the primary synthesizers of TNF
PMID:1431106
TNF induced tumoricidal activity of macrophages.
PMID:14607933, 14625680
TNF and IFNG cooperate in the activation of macrophages.
PMID:18633355
TNF is pro-angiogenic facror.
PMID:23510023, PMID:23170255
TRAIL, FASL and TNF provides Dendritic cell tumor killing activity.() 
L10 stimulates HO1 expression via MAPK p38 stimulation. HO-1 mediates IL-10-induced suppression of TNF- production and IL-10-induced suppression of MMP9 and INOS expression
PMID:22955274
SHIP inhibit MAPKp38 activation and prevent MNK1 phosphorylation by inhibiting the p38 MAPK pathway downstream of IL10. MNK1 regulates TNFa mRNA polysome assembly and upregulates TNFa translation.IL-10 Inhibits TNF Translation through SHIP1-mediated Inhibition of Mnk1
PMID:15699106, PMID:12646658
Phosphorylated STAT1 binds to TNF promoter end induces TNF expression downstream of IFNG.
PMID:15099563
Mast cells produce cytokines TNF-a, TGF-b, IFN-a, IL-1a, IL-1b, IL-5, IL-6,
IL-13, IL-16, IL-18
PMID:24092389
TANs from early tumors are more cytotoxic toward tumor cells and produce higher levels of TNF-α, NO, and H2O2 and, in established tumors, these functions are downregulated and TAN acquire a more protumorigenic phenotype
PMID:21826665
TANs produce TNF and IL1B, probably downstream of TLR4

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. TNF@INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. TNF@default map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. TNF:​TNFR2*:​TRAF1:​TRAF2@INNATE_IMMUNE_CELL_Membrane map
  2. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@INNATE_IMMUNE_CELL_Membrane map
  3. FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. TNF@INNATE_IMMUNE_CELL_Cytosol map → map TNF@default map
  2. rTNF@INNATE_IMMUNE_CELL_Cytosol map → map TNF@INNATE_IMMUNE_CELL_Cytosol map
  3. TNF@INNATE_IMMUNE_CELL_Cytosol map → map TNF@INNATE_IMMUNE_CELL_Cytosol map
  4. TNF@INNATE_IMMUNE_CELL_Cytosol map → map IMMUNE_ACTIVATION@default map
  5. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@INNATE_IMMUNE_CELL_Membrane map → map FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@INNATE_IMMUNE_CELL_Membrane map
  6. TNF@default map + TNFR1*@INNATE_IMMUNE_CELL_Membrane map + TRADD@INNATE_IMMUNE_CELL_Membrane map + TRAF2@INNATE_IMMUNE_CELL_Membrane map + RIPK1@INNATE_IMMUNE_CELL_Membrane map + FADD@INNATE_IMMUNE_CELL_Membrane map → map FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@INNATE_IMMUNE_CELL_Membrane map
  7. TNF@default map + TNFR2*@INNATE_IMMUNE_CELL_Membrane map + TRAF1@INNATE_IMMUNE_CELL_Membrane map + TRAF2@INNATE_IMMUNE_CELL_Membrane map → map TNF:​TNFR2*:​TRAF1:​TRAF2@INNATE_IMMUNE_CELL_Membrane map
  8. TNF@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
As Catalyser:
  1. gMIF@INNATE_IMMUNE_CELL_Cytosol map → map rMIF@INNATE_IMMUNE_CELL_Cytosol map
  2. MIF@INNATE_IMMUNE_CELL_Cytosol map → map MIF@default map
  3. HMGB1@INNATE_IMMUNE_CELL_Cytosol map → map HMGB1@default map
  4. CXCL1@INNATE_IMMUNE_CELL_Cytosol map → map CXCL1@default map
  5. IL8*@INNATE_IMMUNE_CELL_Cytosol map → map IL8*@default map
  6. gCCR2@INNATE_IMMUNE_CELL_Cytosol map → map rCCR2@INNATE_IMMUNE_CELL_Cytosol map
  7. CD74:​MHC_class_II*@Endoplasmic Reticulum_Membrane map → map CD74:​MHC_class_II*@INNATE_IMMUNE_CELL_Membrane map
  8. MAP3K7@INNATE_IMMUNE_CELL_Cytosol map + TAB2@INNATE_IMMUNE_CELL_Cytosol map + TAB3@INNATE_IMMUNE_CELL_Cytosol map → map (MAP3K7:​TAB2:​TAB3)|​active@INNATE_IMMUNE_CELL_Cytosol map
  9. gIRF1@INNATE_IMMUNE_CELL_Cytosol map → map rIRF1@INNATE_IMMUNE_CELL_Cytosol map
  10. TRAF2@INNATE_IMMUNE_CELL_Membrane map → map degraded
  11. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol map → map IKBKG|​ubi:​IKK_beta_*|​pho:​MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol map
  12. JNK*@INNATE_IMMUNE_CELL_Cytosol map → map JNK*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  13. p38*@INNATE_IMMUNE_CELL_Cytosol map → map p38*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map