Protein GAB2 map

Identifiers
HUGO:GAB2

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS

References
 MAST_CELL  map
 NATURAL_KILLER  map
PMID:16212621, PMID:10982827
Phosphorylation of Gab2 was enhanced by both IL-2 and IL-15 in T cells.
IL-2- and IL-15-induced Gab2-PI3K association and downstream AKT activation in T cells and B cells.
PMID:10849428
IL-2 but not IL-4, IL-12, or IFN-α/β, was able to induce the phosphorylation of Gab2 in NK cells
and induces its association with PI3K (p85).
JAK3 probably plays a pivotal role for in IL-2-dependent Gab2 phosphorylation.
PMID:19909365
GAB2 lthough it has been long recognized that PI3K signaling is important for the regulation of
FcεRI-mediated activation of MCs (161–163), the molecular link between FcεRI and
activation of PI3K

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. GAB2@INNATE_IMMUNE_CELL_Cytosol map
  2. GAB2|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. GAB2@INNATE_IMMUNE_CELL_Cytosol map → map GAB2|​pho@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map → map PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map