Protein CCL5 map

Identifiers
HUGO:CCL5

Maps_Modules
MODULE:RECRUITMENT_OF_IMMUNE_CELLS

References
 NEUTROPHIL  map
 DENDRITIC_CELL  map
 NATURAL_KILLER  map
CASCADE:CCR5
CASCADE:TGFB
PMID:19732719 
Inhibition of TGF-ß signaling downregulates Arginase1, CCL5 and CCL2 expression and upregulates TNF, ICAM1,CCL3 expression (mRNA) in tumor neutrophiles (TAN)
PMID:11698286
IFNA induces surface expression of CCR5 in Dcs. This higher expression of CCR5 was associated with a stronger chemotactic response of IFN-DCs to the β-chemokines CCL5(RANTES), CCL3(MIP-1α), and, especially, CCL4( MIP-1β).
PMID:11790543, PMID:15356122
CCR5 as a critical NK-cell homing receptor,
CCL5 expression at the tumor site determined the effectiveness of the antitumor response, which was associated with infiltration of increased numbers of NK, CD4, and CD8 cells at the tumor site.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CCL5@INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. CCL5@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rCCL5@INNATE_IMMUNE_CELL_Cytosol map → map CCL5@INNATE_IMMUNE_CELL_Cytosol map
    2. CCL5@INNATE_IMMUNE_CELL_Cytosol map → map CCL5@default map
    As Catalyser:
    1. CCR5@INNATE_IMMUNE_CELL_Membrane map → map CCR5@INNATE_IMMUNE_CELL_Membrane map