Identifiers
HUGO:LILRB1

Maps_Modules
MODULE:INPUT_INHIBITORS MODULE:INHIBITION_OF_TUMOR_RECOGNITION MODULE:NK_INHIBITING_RECEPTORS

References
CASCADE:LILRB1
 NATURAL_KILLER 
PMID:15771571, PMID:10591185, PMID:9933109
LILRB1 binds with low affinity to a conserved region in the
α3 domain of essentially all HLA class I glycoproteins, including HLA-A, -B,
-C, -E, -F, and -G. LILRB1 receptors on NK cells can suppress their activation (cytotoxicity) upon encountering HLA classI–bearing
targets (demonstrated for HLA-G, only).

1. LILRB1@INNATE_IMMUNE_CELL_Membrane

1. HLA-G:​LILRB1@INNATE_IMMUNE_CELL_Membrane

1. HLA-G:​LILRB1@INNATE_IMMUNE_CELL_Membrane → TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR
2. LILRB1@INNATE_IMMUNE_CELL_Membrane + HLA-G@TUMOR_CELL_AS_INDUCTOR_Membrane → HLA-G:​LILRB1@INNATE_IMMUNE_CELL_Membrane