Protein FGF2 map

Identifiers
HUGO:FGF2

Maps_Modules
MODULE:EFFECTOR_INHIBITION MODULE:TUMOR_GROWTH MODULE:ANGIOGENIC_FACTORS MODULE:GROWTH_FACTORS_EXPRESSION

References
 MACROPHAGE  map
 MDSC  map
 MAST_CELL  map
PMID:18776941
Myeloid-derived suppressor cells and macrophages isolated from mouse tumors displayed activated Stat3 and induced angiogenesis in an in vitro tube formation assay via Stat3 induction of angiogenic factors, including VEGF and bFGF.
PMID:18633355
TAM express many pro-angiogenic and angiogenesis-modulating factors in vitro, such as VEGF, basic fibroblast growth factor (bFGF, also known as FGF2), tumour necrosis factor (TNF), interleukin 1 (IL1), chemokine (C-X-C motif) ligand 8 (CXCL8; also known as IL8), cyclooxygenase 2 (COX2, also known as PTGS2), plasminogen activator, urokinase (uPA, also known as PLAU), platelet derived growth factor beta.
PMID:19508171
FGF drives tumor growth
PMID:11874475
Mast cells express end secrete FGF2

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. FGF2@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. FGF2@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
    2. FGF2@INNATE_IMMUNE_CELL_Cytosol map → map TUMOR_GROWTH@TUMOR_CELL_AS_EFFECTOR map
    3. rFGF2@INNATE_IMMUNE_CELL_Cytosol map → map FGF2@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: