Identifiers
HUGO:TNFSF10
Maps_Modules
MODULE:TUMOR_KILLING MODULE:EFFECTOR_ACTIVATION MODULE:APOPTOSIS_INDUCING_LIGANDS MODULE:EXOCYTOSIS_AND_PHAGOCYTOSIS
References
NATURAL_KILLER
DENDRITIC_CELL
NEUTROPHIL
CASCADE:IFNAB
CASCADE:IFNG
CASCADE:IL12
PMID:9858524
Mature CD56(+) NK cells mediate TRAIL-dependent and FasL-dependent cytotoxicity of tumor cells.
PMID:11257133
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis.
Administration of IL-12 selectively upregulated TRAIL expression on NK cells.
IL-12 stimulates TRAIL-mediated antimetastatic activity of NK cells.
The cytotoxicity of NK cells was inhibited partially by anti-TRAIL mAb.
TRAIL is a key effector molecule mediating the IFNG–dependent antimetastatic effect of IL-12.
IFN-γ induced both liver and spleen NK cell TRAIL expression. By contrast, treatment with either IL-12 or α-GalCer did not induce NK cell TRAIL. These data directly supported the conclusion that IFN-γ plays a key role in TRAIL expression and TRAIL-mediated antimetastatic function of NK cells.
PMID:11823516
Human immature dendritic cells express on their cell surface four different cytotoxic TNF family ligands: TNF, lymphotoxin-alpha(1)beta(2), Fas ligand, and TNF-related apoptosis inducing ligand; while cancer cells express the corresponding death receptors. Disruptions of interactions between the four ligands expressed on DCs and corresponding death-signaling receptors expressed on cancer cells using specific Abs or RFc fusion proteins block the cytotoxic activity of DCs directed against cancer cells.
PMID:10811870
I IFN induces TRAIL mRNA expression in DCs and enhances apoptosis of target tumor cells.
PMID:23510023, PMID:23170255
TRAIL, FASL and TNF provides Dendritic cell tumor killing activity.()
PMID:26819959, PMID:25001536
Neutrophils kill tumor cells by TRAIL