Identifiers
HUGO:IL1B
Maps_Modules
MACROPHAGE
MDSC
NEUTROPHIL
DENDRITIC_CELL
MAST_CELL
MODULE:EFFECTOR_INHIBITION
MODULE:TUMOR_GROWTH
MODULE:ANGIOGENIC_FACTORS
CASCADE:P2RX7
CASCADE:TLR2_4
References
PMID:17043764
IL1 signaling has both antitumor effect (low dose of IL B and menbran associated IL1A) and protumor effect (high dose of IL1) in tumor microevironment,
PMID:12598651
Microenvironmental IL-1 beta and, to a lesser extent, IL-1 alpha are required for in vivo angiogenesis and invasiveness of different tumor cells.
PMID:24727385
Tumor-derived IL-1β secreted into the tumor microenvironment has been shown to induce the accumulation of MDSC that promotes tumor growth.
PMID:18977329
IL-1β activates MDSC in vitro and in vivo through an IL-1RI/NF-κB pathway.
mRNA expression of several NF-κB target genes such is IL6, IL1B,TNF are IL1B/NFkB dependent in MSDC
PMID:17942936
IL-1R–deficient mice have a delayed accumulation of MDSC and reduced primary and metastatic tumor progression. Accumulation of MDSC and tumor progression are partially restored by IL-6, indicating that IL-6 is a downstream mediator of the IL-1β–induced expansion of MDSC. IL-1Ra (IL-1R antagonis) −/− MDSC are more suppressive than BALB/c MDSC.
PMID:18633355
TAM express many pro-angiogenic and angiogenesis-modulating factors in vitro, such as VEGF, basic fibroblast growth factor (bFGF, also known as FGF2), tumour necrosis factor (TNF), interleukin 1 (IL1), chemokine (C-X-C motif) ligand 8 (CXCL8; also known as IL8), cyclooxygenase 2 (COX2, also known as PTGS2), plasminogen activator, urokinase (uPA, also known as PLAU), platelet derived growth factor beta.
PMID:15099563
Mast cells produce cytokines TNF-a, TGF-b, IFN-a, IL-1a, IL-1b, IL-5, IL-6,
IL-13, IL-16, IL-18
PMID:21826665
TANs produce TNF and IL1B, probably downstream of TLR4
→ trILB1@INNATE_IMMUNE_CELL_Cytosol
→ IL1B@INNATE_IMMUNE_CELL_Cytosol