Identifiers
HUGO:CCL3
Maps_Modules
MODULE:RECRUITMENT_OF_IMMUNE_CELLS
References
NEUTROPHIL
MACROPHAGE
DENDRITIC_CELL
CASCADE:TGFB
CASCADE:CCR5
CASCADE:TLR2_4
PMID:19732719
Inhibition of TGF-ß signaling downregulates Arginase1, CCL5 and CCL2 expression and upregulates TNF, ICAM1,CCL3 expression (mRNA) in tumor neutrophiles (TAN)
PMID:11698286
IFNA induces surface expression of CCR5 in Dcs. This higher expression of CCR5 was associated with a stronger chemotactic response of IFN-DCs to the β-chemokines CCL5(RANTES), CCL3(MIP-1α), and, especially, CCL4( MIP-1β).
PMID:16410834
T-bet upregulates the production of proinflammatory cytokine IL-1α and chemokines macrophage inflammatory protein-1α (MIP-1α) and downregulatesthymus- and activation-related chemokine (TARC) by DCs.