Protein CTSS map

Identifiers
HUGO:CTSS

Maps_Modules
MODULE:IMMUNE_STIMULATION MODULE:ANTIGEN_PRESENTATION MODULE:EFFECTOR_ACTIVATION

References
 DENDRITIC_CELL  map
CASCADE:IL6
PMID:22157818
CTSS (cathepsin S), CTSB (cathepsin B) and CTSL (cathepsin L) are active in DC phagosomes.
Phagosomal NOX2 activity via ROS inhibits the activities of local cysteine (B/S/L ), but not aspartic (D/E), cathepsins
PMID:22424724
Cathepsin S dominates autoantigen processing in human thymic dendritic cells.
PMID:10072073, PMID:10562280
Cathepsin S provides Ii (CD74) degradation in dendritic cells.
PMID:16286017
cathepsin S activity was responsible for the IL-6-mediated decrease in MHCII αβ dimer, Ii, and H2-DM levels in DCs.

Modifications:
In compartment: PHAGOSOME/ENDOSOME/LYSOSOME_Membrane
  1. CTSS@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. CTSS@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map CTSS@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
    As Catalyser:
    1. CD74:​MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map degraded
    2. Tumor_antigen@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map Tumor_antigen_fragment@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
    3. CD74:​MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map CLIP*:​MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map