Identifiers
HUGO:FYN

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:TUMOR_RECOGNTITON MODULE:NK_ACTIVATING_RECEPTORS

References
 NATURAL_KILLER 
CASCADE:NKP44
CASCADE:NKP30
CASCADE:NKP46
CASCADE:SLAMF7
CASCADE:LFA1
CASCADE:INTEGRIN_A4B1
CASCADE:INTEGRIN_A5B1
PMID:12731048, PMID:20814939
Upon engagement of activating receptors, the tyrosine-containing adapters undergo tyrosine phosphorylation mediated by Src family kinases (SFKs) .
Cross-linking of Nkp30 or Nkp46 or NKp44 resulted in strong tyrosine phosphorylation of LCK anf FYN kinases.
PMID:10591186, PMID:24440149
Cross-Linking of LFA-1 induces tyrosine Phosphorylation of DNAM-,FYN probably phosphorylates DNAM1 Y322 in NK cells
PMID:22683124
Fyn-deficient NK cells exhibited defective killing.
PMID:19909365
FYN is adaptor protein f Fc epsilon RI signaling in mast cells

1. FYN@INNATE_IMMUNE_CELL_Cytosol
2. FYN|​pho|​active@INNATE_IMMUNE_CELL_Cytosol

1. FYN@INNATE_IMMUNE_CELL_Cytosol → FYN|​pho|​active@INNATE_IMMUNE_CELL_Cytosol

1. CD247:​NKp30*@INNATE_IMMUNE_CELL_Membrane → CD247|​pho:​NKp30*@INNATE_IMMUNE_CELL_Membrane
2. CD247:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane → CD247:​CD247|​pho:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane
3. CD11a*:​CD18*:​DNAM1*|​pho@INNATE_IMMUNE_CELL_Membrane → CD11a*:​CD18*:​DNAM1*|​pho|​pho@INNATE_IMMUNE_CELL_Membrane
4. CRKL@INNATE_IMMUNE_CELL_Cytosol + PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol → CRKL:​PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol
5. SH2D1B@INNATE_IMMUNE_CELL_Membrane + s1747 → SH2D1B|​pho:​SLAMF7|​pho|​hm2@INNATE_IMMUNE_CELL_Membrane
6. DAP12*:​NKp44*@INNATE_IMMUNE_CELL_Membrane → DAP12*|​pho:​NKp44*@INNATE_IMMUNE_CELL_Membrane
7. SLAMF7@TUMOR_CELL_AS_INDUCTOR_Membrane + SLAMF7@INNATE_IMMUNE_CELL_Membrane → s5128