Protein CANX map

Identifiers
HUGO:CANX

Maps_Modules
MODULE:IMMUNE_STIMULATION MODULE:ANTIGEN_PRESENTATION MODULE:EFFECTOR_ACTIVATION

References
 DENDRITIC_CELL  map
PMID:16181333, PMID:22076556
Upon dissociation from CNX, the heavy chain of (MHC) class I binds β2 microglobulin (b2m) and is incorporated into the peptide-loading complex.
PMID:17204652
DCs, which are biased for MHCI cross-presentation, were enriched in Tap1, Tap2, calreticulin, calnexin, Sec61, ERp57, ERAAP, as well as cystatin B and C, all of which are involved in MHCI presentation or inhibition of enzymes that process peptides for MHCII presentation.

Modifications:
In compartment: Endoplasmic Reticulum_Membrane
  1. CANX@Endoplasmic Reticulum_Membrane map
  2. CANX@Endoplasmic Reticulum_Membrane map
Participates in complexes:
In compartment: Endoplasmic Reticulum_Membrane
  1. CANX:​MHC_class_I*@Endoplasmic Reticulum_Membrane map
Participates in reactions:
As Reactant or Product:
  1. CANX:​MHC_class_I*@Endoplasmic Reticulum_Membrane map → map MHC_class_I*@Endoplasmic Reticulum_Membrane map + CANX@Endoplasmic Reticulum_Membrane map
  2. MHC_class_I*@Endoplasmic Reticulum_Membrane map + CANX@Endoplasmic Reticulum_Membrane map → map CANX:​MHC_class_I*@Endoplasmic Reticulum_Membrane map
As Catalyser: