Protein PKA* map

Identifiers
HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612

Maps_Modules
 MACROPHAGE  map
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:IMMUNOSUPPPRESSIVE_CORE_PATHWAYS
CASCADE:IL13

References
REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA
REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB
PMID:18501881, PMID:7890616
Intracellular Ca2+ release induces cAMP Accumulation in Human Monocytes and activation of PKA signaling downstream of IL13.
IL-13 significantly inhibits the ROS generation in all macrophage types, probably, via PLC/Ca2+/cAMP/PKA pathway
PMID:10925299
IL13 activates Arginase activity downstream of cAMP/PKA

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PKA*@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PKA*:​PKA_R*@INNATE_IMMUNE_CELL_Cytosol map
  2. PKA*:​PKA_R*:​cAMP@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. cAMP@INNATE_IMMUNE_CELL_Cytosol map + PKA*:​PKA_R*@INNATE_IMMUNE_CELL_Cytosol map → map PKA*:​PKA_R*:​cAMP@INNATE_IMMUNE_CELL_Cytosol map
  2. PKA*:​PKA_R*:​cAMP@INNATE_IMMUNE_CELL_Cytosol map → map PKA_R*:​cAMP@INNATE_IMMUNE_CELL_Cytosol map + PKA*@INNATE_IMMUNE_CELL_Cytosol map
  3. PKA*@INNATE_IMMUNE_CELL_Cytosol map → map ROS_production@default map
As Catalyser:
  1. L-arginine@INNATE_IMMUNE_CELL_Cytosol map → map Urea@INNATE_IMMUNE_CELL_Cytosol map + L-ornitine@INNATE_IMMUNE_CELL_Cytosol map