Identifiers
HUGO:PLCG1
Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
References
NATURAL_KILLER
MACROPHAGE
MAST_CELL
CASCADE:IL13
CASCADE:SLAMF7
CASCADE:2B4
CASCADE:Fc_gamma_RI
CASCADE:Fc_gamma_RII
CASCADE:Fc_gamma_RIII
CASCADE:IFNAB
PMID:25960930
IFNα induces PKC-θ auto-phosphorylation in NK cells via P3K and PLC pathways and improves the degranulation via PKC-θ signaling
PMID:11169415, PMID:10072481, PMID:8649391
Tyrosine phosphorylation of LAT led to the recruitment of intracytoplasmic signaling molecules including phospholipase Cgamma and Grb2
and activation of phosphatidylinositol pathway in NK cells.
PMID:2536067, PMID:1281218
Ligation of Fc gamma RIII alpha (CD16) induces the tyrosine phosphorylation of both phospholipase C (PLC)-gamma 1 and PLC-gamma 2 in natural killer cells and stimulates expression of many cytokines via Ca('2+) -depend mechanism.
PMID:8226994
Stimulation of the human monocytic cell line THP-1 by cross-linking either Fc gamma receptor I (Fc gamma RI) or Fc gamma receptor II (Fc gamma RII) gave rise to the rapid phosphorylation of multiple intracellular proteins. The pattern of proteins that were phosphorylated appeared to be identical. Analysis of these proteins by specific immunoprecipitation indicated that stimulation through either receptor did indeed give rise to phosphorylation of the same set of proteins. These included: Fc gamma RII, phospholipase C (PLC) gamma 1, PLC gamma 2, Vav, GAP
PMID:10781611
The adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cells.
Co-immunoprecipitation experiments revealed a constitutive association of p36 LAT with both FcgammaRI and FcgammaRIIa immunoprecipitates, and an activation-induced association of LAT with PLCgamma1, Grb2, and the p85 subunit of phosphatidylinositol 3-kinase.
bone marrow-derived macrophages from LAT-deficient mice displayed reduced phagocytic efficiency in comparison to the macrophages from wild-type mice.
PMID:9535722
IL13 induces phosporylation of IRS2 and PLCG1 which is probably a PLC responsible for downstream IL13 dependent Ca2+ mobilization signaling and assosiation of IRS2 and PLCG1
PMID:7890616, PMID:10925299
PCL (probably PCLG1) induces hydrolysis of phosphoinositides and activates InsP3-induced intracellular Ca2+ release downstream of IL13. Intracellular Ca2+ release release induces cAMP Accumulation in Human monocytes and activation of PKA signaling downstream of IL13.
PMID:7890616
IL13 inhibits ROI production downstream of cAMP/PKA in all macrophage types
PMID:19909365
The phosphorylation of LAT1
together with the generation of PIP3 in the lipid raft environment recruits proteins such as
PLC-γ1 and PLC-γ2