Protein CD80 map

Identifiers
HUGO:CD80

Maps_Modules
 DENDRITIC_CELL  map
 MACROPHAGE  map
MODULE:MARKERS_DC
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CHEKPOINTS
MODULE:EFFECTOR_ACTIVATION
CASCADE:MIF
CASCADE:IL3
CASCADE:IL10
CASCADE:TLR2_4
CASCADE:FLT3LG
CASCADE:TNF
CASCADE:IFNAB
CASCADE:IFNG

References
PMID:15197224, PMID:7523569, PMID:9359474
The Linkage of Innate to Adaptive Immunity via Maturing Dendritic Cells In Vivo Requires CD40 Ligation in Addition to Antigen Presentation and CD80/86 Costimulation.
PMID:25582338
The expression levels of CD80 and CD83, the molecules involved in T-cell activation, was similar between the two DC subsets (IL4 and IL15)
PMID:11964292, PMID:14764699
IFNAR signaling upregulates surface expression of CD80, CD86, CD40.Probably via STAT1
PMID:22437870
CD80 and CD86 act lic coactivators of T-cells when they interact with CD28 and
inhibit T-cells via interactions with CTLA4
PMID:25215878
FLT3 ligand upregulates surface expression of CD80 in DCs.
PMID:23390297
MIF inhitits expression of M1 markers such as TNF, IL12p40, COX2, INOS, IRF-5, MHC-II, CD11c, CD80, CD86 and MIF induces expression of M2 markers as IL10, stabilin-1, MRC-1, CD23
 15034038
IL3 induces CD80, CD86, CD40 surface expression in pDC
PMID:7512027
IL-10 inhibits surface expression CD80 (B7) on monocytes, even following induction of these molecules by IL4 or IFNG and diminishes the antigen-presenting capacity of monocytes.
PMID:20231889
Dcs Stat5-Tg mice are expressing ot surface high levels of MHC-II and costimulatory molecules such as CD80, CD86 and CD54 (ICAM1) and have increased level of I12 secretion (.)
Expression of CD83, a and CD80 and was significantly enhanced by the FLT3L
 11207245
I IFN receptor signaling regulates antigen cross-presentation to CD8(+) T cells. (), probably via upregulation of CD80, CD86, CD40, CD83 and MHC class II and CD11c,
PMID:17513775
Probably via STAT1(demondrtated for CD40 and CD11c PMID:14764699, and for CD40, CD80, CD86, and MHC II  )
INFG up-regulates ICAM1 and CD80 (B7) surface expression in monocytes. And IL10 inhibit it.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CD80@INNATE_IMMUNE_CELL_Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CD80@INNATE_IMMUNE_CELL_Membrane map
In compartment: MARKERS_DC
  1. CD80@MARKERS_DC map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CD80:​CD86@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. CD80@INNATE_IMMUNE_CELL_Membrane map + CD86@INNATE_IMMUNE_CELL_Membrane map → map CD80:​CD86@INNATE_IMMUNE_CELL_Membrane map
  2. CD80@INNATE_IMMUNE_CELL_Cytosol map → map CD80@INNATE_IMMUNE_CELL_Membrane map
  3. CD80@INNATE_IMMUNE_CELL_Membrane map → map Immune_checkpoints_T_cells_Activators@default map
  4. CD80:​CD86@INNATE_IMMUNE_CELL_Membrane map → map Antigen_presentation@default map
As Catalyser: