Protein CXCL10 map

Identifiers
HUGO:CXCL10

Maps_Modules
 MACROPHAGE  map
MODULE:RECRUITMENT_OF_IMMUNE_CELLS
 NATURAL_KILLER  map
CASCADE:CXCR3
CASCADE:IFNAB
CASCADE:TLR2_4
 DENDRITIC_CELL  map

References
PMID:18922917
Significantly lower numbers of tumor-infiltrating NK cells were detected in CXCR3−/− mice, and the capacity of adoptively transferred CXCR3−/− NK cells to accumulate in the tumor was severely impaired.
Ectopic expression of CXCL10 by tumor cells increased the numbers of NK cells in the tumors and prolonged NK cell–dependent survival.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CXCL10@INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. CXCL10@default map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CXCL10:​CXCR3@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. CXCL10@INNATE_IMMUNE_CELL_Cytosol map → map CXCL10@default map
  2. CXCL10@default map + CXCR3@INNATE_IMMUNE_CELL_Membrane map → map CXCL10:​CXCR3@INNATE_IMMUNE_CELL_Membrane map
  3. CXCL10:​CXCR3@INNATE_IMMUNE_CELL_Membrane map → map RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol map
  4. rCXCL10@INNATE_IMMUNE_CELL_Cytosol map → map CXCL10@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser: