Protein MLCK* map

Identifiers
HUGO:MYLK HUGO:MYLK2

Maps_Modules
MODULE:TUMOR_KILLING MODULE:EFFECTOR_ACTIVATION MODULE:EXOCYTOSIS_AND_PHAGOCYTOSIS

References
 MACROPHAGE  map
PMID:25712372, PMID:12194823
MLCK and ROCK phosphorylares RLC
inhibition of the Rho → ROK → myosin-II pathway caused a decreased accumulation of Arp2/3 complex and F-actin around bound particles, which led to a reduction in CR-mediated phagocytic engulfment.
MLCK caused a significant reduction of both myosin-IIA localization and particle uptake, while it did not affect actin or Arp2/3 complex recruitment, suggesting a role for MLCK and myosin-IIA in later steps of phagosome formation
PMID:10733514
ERK2 activated MLCK, resulting in phosphorylation of the MLCK substrate or of the myosin light chain itself.
And induces phagocytosis.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. MLCK*@INNATE_IMMUNE_CELL_Cytosol map
  2. MLCK*|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. MLCK*@INNATE_IMMUNE_CELL_Cytosol map → map MLCK*|​pho@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol map → map ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho@INNATE_IMMUNE_CELL_Cytosol map