Gene FASL* map

Identifiers
HUGO:FASLG

Maps_Modules
MODULE:TUMOR_KILLING MODULE:EFFECTOR_ACTIVATION MODULE:APOPTOSIS_INDUCING_LIGANDS MODULE:EXOCYTOSIS_AND_PHAGOCYTOSIS

References
 NATURAL_KILLER  map
 DENDRITIC_CELL  map
CASCADE:NKG2A
CASCADE:Fc_gamma_RIII
CASCADE:2B4
CASCADE:IFNAB
CASCADE:IL18
CASCADE:LFA1
PMID:12967644
IFNA signaling via STAT1 up-regulates gene expression of cytolytic effectors Fas-L in NK cells.
PMID:8892629
IFN-gamma-inducing factor (IL18) up-regulates Fas ligand-mediated cytotoxic activity (via upregulation of FASL expression) of murine natural killer cell clones
PMID:15120186
2B4 and LFA1 signalings upregulates FasL mRNA and surface expression in NK cells.
FasL transcription is inhibited by NKG2A/CD94
PMID:7650486, PMID:9973469, PMID:9374532
NF-AT, migrates to the nucleus and activates transcription of cytokines TNF,  GM-CSF , IL-2,  IL-4. Fas ligand ( FasL ) and, possibly, IFNG.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gFASL*@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gFASL*@INNATE_IMMUNE_CELL_Cytosol map → map rFASL*@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: