Gene TRAIL* map

Identifiers
HUGO:TNFSF10

Maps_Modules
MODULE:TUMOR_KILLING MODULE:EFFECTOR_ACTIVATION MODULE:APOPTOSIS_INDUCING_LIGANDS MODULE:EXOCYTOSIS_AND_PHAGOCYTOSIS

References
CASCADE:IFNAB
CASCADE:IFNG
CASCADE:IL12
 NATURAL_KILLER  map
 DENDRITIC_CELL  map
PMID:11257133
Administration of IL-12 selectively upregulated TRAIL expression on NK cells.
IL-12 stimulates TRAIL-mediated antimetastatic activity of NK cells.
The cytotoxicity of NK cells was inhibited partially by anti-TRAIL mAb.
TRAIL is a key effector molecule mediating the IFNG–dependent antimetastatic effect of IL-12.
IFN-γ induced both liver and spleen NK cell TRAIL expression. By contrast, treatment with either IL-12 or α-GalCer did not induce NK cell TRAIL. These data directly supported the conclusion that IFN-γ plays a key role in TRAIL expression and TRAIL-mediated antimetastatic function of NK cells.
PMID:10811870, PMID:17617740 
I IFN induces TRAIL mRNA expression in DCs and enhances apoptosis of target tumor cells. Probably via STAT1 and IFR1 (PMID17617740 )

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gTRAIL*@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gTRAIL*@INNATE_IMMUNE_CELL_Cytosol map → map rTRAIL*@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: