Gene TBX21 map

Identifiers
HUGO:TBX21

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:MIRNA_TF_IMMUNOSTIMULATORY

References
 NATURAL_KILLER  map
 MACROPHAGE  map
 DENDRITIC_CELL  map
CASCADE:TGFB
CASCADE:Fc_gamma_RIII
CASCADE:IL2
CASCADE:IL15
CASCADE:IL18
CASCADE:IL12
CASCADE:IL21
CASCADE:IFNG
PMID:10761931, PMID:12055627, PMID:18768831, PMID:16713975, PMID:15084276, PMID:12244150
The pattern of T-bet expression correlates well with the production of IFNG in NK cells.
The induction of T-bet expression and secretion of IFNγ in NK cells that produce IFNγ
exists only upon treatment with IL-2, IL15,IL18, IL21 and IL-12 and CD16 pathway activation..
T-bet regulates IFNG expression in NK cells, probably via chromatin remodeling.
PMID:18768831, PMID:16713975
SMAD2, SMAD3 and SMAD4 participate in suppression of TBX21 (T-BET) promoter activity downstream of TGFB. TBX21 is involeved in IFNG gene activation.
 11752460 
 IFN-γ induces T-bet expression in monocytes, macrophages, and dendritic cells (DC) via STAT1.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gTBX21@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gTBX21@INNATE_IMMUNE_CELL_Cytosol map → map rTBX21@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: