Identifiers
HUGO:ARG2
Maps_Modules
MACROPHAGE
MODULE:TUMOR_KILLING
MODULE:EFFECTOR_ACTIVATION
MODULE:NO_ROS_PRODUCTION
CASCADE:IL10
References
PMID:12193690
A hallmark of “alternative activation” (M2) of macrophages
is high arginase activity, which competes with inducible NO
synthase for L-arginine, the common substrate
of both enzymes. IL-10 induces ARG2 (arginase-2) expression