Protein IDO1 map

Identifiers
HUGO:IDO1

Maps_Modules
MODULE:EFFECTOR_INHIBITION MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_EXPRESSION MODULE:IMMUNE_SUPPRESSION

References
 DENDRITIC_CELL  map
 MACROPHAGE  map
CASCADE:IFNG
CASCADE:TLR2_4
CASCADE:TNF
PMID:15459668
Indoleamine 2,3-dioxygenase (IDO) is an enzyme that degrades the essential amino acid tryptophan.Cells expressing IDO can suppress T-cell responses and promote tolerance
IDO could be expressed by Macrophages and DCs.
he mouse and human IDO gene promoters contain multiple sequence elements that confer responsiveness to type I (IFN-/) and, more potently, type II (IFN-) interferon.
IDO-expressing host APCs (whatever their subtype) might contribute to a state of local immunosuppression in tumour-draining lymph nodes, and might help to induce systemic tolerance to tumour antigens as well.
PMID:8663541
IFNG induces IDO expression via STAT1 and IRF-1 in DC
PMID:11477543
TLR4 -induced systemic IDO is largely dependent on TNF-alpha rather than IFN-gamma in macrophages.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IDO1@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rIDO1@INNATE_IMMUNE_CELL_Cytosol map → map IDO1@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. Tryptophan@INNATE_IMMUNE_CELL_Cytosol map → map N-formyl-kynurenine@INNATE_IMMUNE_CELL_Cytosol map