RNA SHIP1* map

Identifiers
HUGO:INPP5D

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSUPPPRESSIVE_CORE_PATHWAYS

References
 MACROPHAGE  map
 NATURAL_KILLER  map
CASCADE:IL10
CASCADE:IL4
PMID:19359473, PMID:22378844
Inositol phosphatase SHIP1 is a primary and direct target of miR-155.
miR-155 upregulates IFNG production in natural killer cells via SHIP1 downregulation.
PMID:20435894
IL-10 inhibits miR-155 expression via STAT3. 3--UTR of SHIP1 is targeted by miR-155. Inhibition of Mir155 expression upregulates SHIP downstream of IL10. ().

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. rSHIP1*@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. MIR155:​SHIP1*@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. rSHIP1*@INNATE_IMMUNE_CELL_Cytosol map → map SHIP1*@INNATE_IMMUNE_CELL_Cytosol map
  2. gSHIP1*@INNATE_IMMUNE_CELL_Cytosol map → map rSHIP1*@INNATE_IMMUNE_CELL_Cytosol map
  3. MIR155:​SHIP1*@INNATE_IMMUNE_CELL_Cytosol map → map degraded
  4. arMIR155@INNATE_IMMUNE_CELL_Cytosol map + rSHIP1*@INNATE_IMMUNE_CELL_Cytosol map → map MIR155:​SHIP1*@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser: