Gene IL18 map

Identifiers
HUGO:IL18

Maps_Modules
 MACROPHAGE  map
MODULE:RECRUITMENT_OF_IMMUNE_CELLS
MODULE:INPUT_ACTIVATORS
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
MODULE:EFFECTOR_ACTIVATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION
CASCADE:IL13
CASCADE:IL4
PMID:24204259
IL4RA signaling upregulates IL18 expression and downregulates IL10 expression and also mRNA expression of IL-23p19 and INHBA (activin A), cytokines previously implicated in promoting Th2 responses

References
PMID:16413922
NFKBID (IkBNS) inhibit late phase (after 3h) of expression of proinflanotory cytokines
Il-12p40 (IL-12p40), Il-18 (IL-18) and Csf3 (G_CSF).

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gIL18@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gIL18@INNATE_IMMUNE_CELL_Cytosol map → map rIL18@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: