Gene SMAD3 map

Identifiers
HUGO:SMAD3

Maps_Modules
MODULE:INPUT_INHIBITORS MODULE:IMMUNE_SUPPRESSION MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS

References
CASCADE:TGFB
CASCADE:IL12
CASCADE:IL18
CASCADE:IL15
PMID:16713975
SMAD2, SMAD3 and SMAD4 participate in suppression of TBX21 (T-BET) promoter activity downstream of TGFB.
costimulation of NK cells with IL-12 and IL-18 or with IL12 and IL15 downregulated SMAD3 transcript and protein level.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gSMAD3@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gSMAD3@INNATE_IMMUNE_CELL_Cytosol map → map rSMAD3@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: