Identifiers
HUGO:VEGFA
Maps_Modules
MACROPHAGE
MDSC
DENDRITIC_CELL
MODULE:EFFECTOR_INHIBITION
MODULE:TUMOR_GROWTH
MODULE:ANGIOGENIC_FACTORS
CASCADE:LACTIC
CASCADE:MIF
CASCADE:IL4
CASCADE:CSF2
CASCADE:IFNAB
NEUTROPHIL
References
PMID:21372296
HMGB1 markedly increased the expression of the genes for VEGF, and TGFB1 in
peritoneal macrophages.
PMID:23390297, PMID:22461508
MIF signaling induces angiogenesis provavly via upregulation of MMP9, VEGF expression.
PMID:22067385
c-MYC is expressed in tumor-associated macrophages, and its inhibition blocks the expression of protumoral genes including VEGF, MMP9, HIF-1A, and TGFB.
PMID:20644162
Cytokine-induced CD33+ human MDSCs have upregulated iNOS, TGFβ, VEGF.
PMID:18776941
Myeloid-derived suppressor cells and macrophages isolated from mouse tumors displayed activated Stat3 and induced angiogenesis in an in vitro tube formation assay via Stat3 induction of angiogenic factors, including VEGF and bFGF.
PMID:25043024
Lactic acid is sufficient to induce Vegf and Arg1 via HIF1α.
Lactic acid, probably via HIF1A polarizes macrophages to an M2-Iike state that is critical for tumour growth
MIF signaling induces angiogenesis probavly via upregulation of MMP9, VEGF expression in macrophages and activates tumor invasion
PMID:20237412
IFN-β regulates expression of homing and angiogenic factors in neutrophils.
IFNB downregulates expression Cxcr4, Vegf, and Mmp9 in neutrophils
additionally Stat3 and c-myc are downregulated by IFN-β.
(STAT3 is known to be required for full activation of the Cxcr4 gene )