Gene HIF1A map

Identifiers
HUGO:HIF1A

Maps_Modules
 MACROPHAGE  map
MODULE:IMMUNOSUPPPRESSIVE_CORE_PATHWAYS
MODULE:MIRNA_TF_IMMUNOSUPPRESSIVE
CASCADE:IL4
CASCADE:IL13
CASCADE:IFNG

References
PMID:20194441
IFNG enhanced the synthesis of HIF-1A mRNA.
PMID:24006507
HIF1a induces MIF expression of macrophages after hypoxia.
IL4+IL13 inhibit MIF expression via inhibition of HIF1a expression.
PMID:22067385
c-MYC is expressed in tumor-associated macrophages, and its inhibition blocks the expression of protumoral genes including VEGF, MMP9, HIF-1A, and TGFB.
IL4 downregulates HIF1a translation

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gHIF1A@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gHIF1A@INNATE_IMMUNE_CELL_Cytosol map → map rHIF1A@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: