Gene CXCR4 map

Identifiers
HUGO:CXCR4

Maps_Modules
MODULE:RECRUITMENT_OF_IMMUNE_CELLS
 MDSC  map
 NEUTROPHIL  map
 MACROPHAGE  map
CASCADE:PGE2
CASCADE:IFNAB

References
PMID:20644254
HIF2a induces macrophage migration via upregulation of CXCR4, FN1 expression and upregulation of M-CSFR protein level.
PMID:20237412
IFN-β regulates expression of homing and angiogenic factors in neutrophils.
IFNB downregulates expression Cxcr4, Vegf, and Mmp9 in neutrophils
additionally Stat3 and c-myc are downregulated by IFN-β.
(STAT3 is known to be required for full activation of the Cxcr4 gene )

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gCXCR4@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gCXCR4@INNATE_IMMUNE_CELL_Cytosol map → map rCXCR4@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: