Protein TIMP2 map

Identifiers
HUGO:TIMP2

Maps_Modules
MODULE:EFFECTOR_INHIBITION MODULE:TUMOR_GROWTH MODULE:MATRIX_REMODELLING

References
 MACROPHAGE  map
 MDSC  map
CASCADE:TLR2_4
PMID:1629188
TIMP1 and TIMP2 are produced by macrophages.
TIMP1 production is upregulated by TLR4 (LPS) TIMP2 production is inhibited by TLR4 signaling.
PMID:22735808
TIMP-2 as a negative regulator of MDSCs in tumors
PMID:24437600
TIMP2 drives "normalization" of the tumor microenvironment

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. TIMP2@INNATE_IMMUNE_CELL_Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. TIMP2@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. TIMP2@INNATE_IMMUNE_CELL_Membrane map → map MATRIX_REMODELLING@default map
    2. TIMP2@INNATE_IMMUNE_CELL_Cytosol map → map TIMP2@INNATE_IMMUNE_CELL_Membrane map
    As Catalyser: