Protein PDGFB map

Identifiers
HUGO:PDGFB

Maps_Modules
MODULE:EFFECTOR_INHIBITION MODULE:TUMOR_GROWTH MODULE:ANGIOGENIC_FACTORS

References
 MACROPHAGE  map
 MAST_CELL  map
PMID:18633355
TAM express many pro-angiogenic and angiogenesis-modulating factors in vitro, such as VEGF, basic fibroblast growth factor (bFGF, also known as FGF2), tumour necrosis factor (TNF), interleukin 1 (IL1), chemokine (C-X-C motif) ligand 8 (CXCL8; also known as IL8), cyclooxygenase 2 (COX2, also known as PTGS2), plasminogen activator, urokinase (uPA, also known as PLAU), platelet derived growth factor beta.
PMID:24359404
PDGF signaling drives tumor growth
PMID:15099563
Mast cells produce heparin, interleukin-8 (IL-8) and vascular
endothelial cell growth factor (VEGF), which induce
neovascularization, histamine, which is an immunosuppressant,
mitogenic factors, such as platelet-derived
growth factor (PDGF), nerve GF (NGF), stem-cell factor
(SCF), and proteases, which disrupt the surrounding
matrix and facilitate metastases.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PDGFB@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. PDGFB@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
    2. PDGFB@INNATE_IMMUNE_CELL_Cytosol map → map TUMOR_GROWTH@TUMOR_CELL_AS_EFFECTOR map
    As Catalyser: