RNA FLT3 map

Identifiers
HUGO:FLT3

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:IMMUNE_STIMULATION MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS

References
 DENDRITIC_CELL  map
CASCADE:TLR2_4
CASCADE:FLT3LG
PMID:20510871
PU.1 as a critical regulator of both conventional and plasmacytoid DC development. It is directly upregulates Flt3  gene activation.
PMID:16418395
FLT3L induces PU.1 and STAT3 mRNA expression in DC progenitors and downregulates GATA1 mRNA expression. At The same time enforced expression of STAT3 or PU.1 in DC progenitors led to the up-regulation of Flt3 mRNA levels, so there is a positive loop in this signaling.  Enforced STAT3 or PU.1 expression instructs progenitors to differentiate into Dcs. Additionaly it induces expression of cytokine receptors for G-CSF, M-CSF, and GM-CSF probably downstream of STAT3.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. rFLT3@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gFLT3@INNATE_IMMUNE_CELL_Cytosol map → map rFLT3@INNATE_IMMUNE_CELL_Cytosol map
    2. rFLT3@INNATE_IMMUNE_CELL_Cytosol map → map FLT3@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: