Protein Actin cytoskeletal* map

Identifiers
HUGO:ACTA1 HGNC:129 ENTREZ:58 UNIPROT:P68133 GENECARDS:ACTA1 HUGO:ACTA2 HGNC:130 ENTREZ:59 UNIPROT:P62736 GENECARDS:ACTA2 HUGO:ACTB HGNC:132 ENTREZ:60 UNIPROT:P60709 GENECARDS:ACTB HUGO:ACTC1 HGNC:143 ENTREZ:70 UNIPROT:P68032 GENECARDS:ACTC1 HUGO:ACTG1 HGNC:144 ENTREZ:71 UNIPROT:P63261 GENECARDS:ACTG1

Maps_Modules
MODULE:IMMUNE_STIMULATION MODULE:ANTIGEN_PRESENTATION MODULE:TUMOR_KILLING MODULE:EFFECTOR_ACTIVATION MODULE:EXOCYTOSIS_AND_PHAGOCYTOSIS

References
REACTOME:49626 KEGG:58 ATLASONC:GC_ACTA1 WIKI:ACTA1
REACTOME:49566 KEGG:59 ATLASONC:GC_ACTA2 WIKI:ACTA2
REACTOME:49576 KEGG:60 ATLASONC:ACTBID42959ch7p22 WIKI:ACTB
REACTOME:49595 KEGG:70 ATLASONC:GC_ACTC1 WIKI:ACTC1
REACTOME:49603 KEGG:71 ATLASONC:GC_ACTG1 WIKI:ACTG1
 DENDRITIC_CELL  map
 NATURAL_KILLER  map
 MACROPHAGE  map
PMID:18802007
Disruption of actin polymerization inhibits the up-regulation of surface MHCII in a dose-dependent manner in DC.
 MAST_CELL  map
CASCADE:CR3
CASCADE:Fc_gamma_RII
CASCADE:IL2
PMID:11766992
Fractalkine via CX3CR1 induces chemotaxis and migration associated actin polymerization in immature as well as in mature DCs.
PMID:9314552, PMID:8570922 , PMID:19741094
Actin is likely to play an important role in phagocytosis since it is concentrated in the macrophage cytoplasm surrounding the particle being engulfed, and since cytochalasin D treatment, which blocks actin polymerization, abrogates phagocytosis without affecting particle binding
PMID:9314552
Syk- macrophages exhibited formation of polymerized actin structures opposing particles bound to the cells by FcgammaRs (actin cups), but failed to proceed to internalization. Interestingly, inhibitors of phosphatidylinositol 3-kinase also blocked FcgammaR-mediated phagocytosis at this stage. Thus, PI 3-kinase may participate in a Syk-dependent signaling pathway critical for FcgammaR-mediated phagocytosis.
PMID:19909365
The Ca2+ influx is an essential trigger for fusion of the Mast Cell granules to the
membrane and the breakdown of the actin cytoskeleton.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. Actin cytoskeletal*@INNATE_IMMUNE_CELL_Cytosol map
  2. Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. Actin cytoskeletal*@INNATE_IMMUNE_CELL_Cytosol map → map Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map
    2. Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map → map Actin polymerization@INNATE_IMMUNE_CELL_Cytosol map
    3. Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map → map Actin cytoskeletal*@INNATE_IMMUNE_CELL_Cytosol map
    4. Actin cytoskeletal*@INNATE_IMMUNE_CELL_Cytosol map → map Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map
    5. Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map → map Actin_polymerization@INNATE_IMMUNE_CELL_Cytosol map
    6. Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map → map Actin cytoskeletal*@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: