Identifiers
HUGO:IL12B
Maps_Modules
MACROPHAGE
MODULE:INPUT_ACTIVATORS
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
MODULE:EFFECTOR_ACTIVATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION
DENDRITIC_CELL
CASCADE:IL13
CASCADE:IL4
PMID:24204259
IL4RA signaling upregulates IL18 expression and downregulates IL10 expression and also mRNA expression of IL-23p19 and INHBA (activin A), cytokines previously implicated in promoting Th2 responses (
CASCADE:MIF
CASCADE:TLR2_4
CASCADE:CSF2
CASCADE:CSF1
References
PMID:16243976
IRF4 downregulates expression of TNFa, IL12p40, IL6 probably via inhibition of NF-kB and JNK signaling pathways.
PMID:12417340
IRF-8/ICSBP and IRF-1 cooperatively stimulate mouse IL-12 p40 promoter activity in macrophages.
IRF-1 can be acetylated by p300. p300 is recruited to the IL-12p40 promoter depending on both ICSBP and IRF-1
and acts as coactivator.
PMID:23390297
MIF inhitits expression of M1 markers such as TNF, IL12p40, COX2, INOS, IRF-5, MHC-II, CD11c, CD80, CD86 and MIF induces expression of M2 markers as IL10, stabilin-1, MRC-1, CD23
PMID:17485448, PMID:10542212
Inhibition of NfkB signaling downstream of ABIN3 inhibits expression of IL8, IL6, TNFa, IL12p40
PMID:16394015 , PMID:19667062, PMID:15067049
Fos inhibits the expression of IL-12 p40 and IFNB and upregulates IL10 production downstream of FOS in macrophages and
PMID:17404308
CSF1 downregulates TNF, IL-23p19, IL-12p40 expression probably via induction of acomulation of p50 homodimer and inhibition of p65/p50 NF-kB signaling.