Identifiers
HUGO:IL10
Maps_Modules
MACROPHAGE
MDSC
DENDRITIC_CELL
MODULE:EFFECTOR_INHIBITION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_EXPRESSION
MODULE:IMMUNE_SUPPRESSION
CASCADE:TGFB
CASCADE:MIF
CASCADE:LGALS1
CASCADE:CSF1
CASCADE:STING
CASCADE:TLR2_4
CASCADE:FLT3LG
CASCADE:IFNG
CASCADE:IL4
References
PMID:21115385
IL10 is immunosuppressive cytokine.
PMID:10623821, PMID:10623821
IL10 expression in macrophages is assosiated
with TAM (M2) phenotype.
PMID:20547845
TLR4 signaling downstream of HMGB1 induces secretion of IL10.
PMID:16713974
RNAi-mediated knockdown of CREB, Fos, and Jun expression resulted in diminished TLR2-induced IL-10 production
GSK3B inhitits activation (DNA binding) of AP-1 factors.
JNK is a classical activator of AP1 transcription factors.
Inhibition of JNK downregulates IL10 expression. Probably via
PMID:15749884
c-Maf binds to the −206/−171 region in the IL-10 promoter and upregulates IL10 expression.
AP1.
PMID:25164013
HMGB1 activates MDSCs via the NF-κB pathway It increases MDSC-mediated production of IL-10, enhanced crosstalk between MDSCs and macrophages, and facilitated the ability of MDSCs to downregulate expression of the T-cell homing receptor L-selectin.
PMID:21191065
regulatory effect of galectin-1 is mediated, in part, through its ability to induce, in an Id3 (inhibitor of DNA binding 3)-dependent manner, the expression of IL-10 in monocytes and MdDCs.
significantly increased IL-10 promoter activity was noted in CD14+ monocytes in the presence of A459-CM, NCI-H460-CM, or galectin-1. Increased IL-10 promoter activity was also found in cells overexpressing Id3
PMID:23390297
MIF induces expression of M2 markers as IL10, stabilin-1, MRC-1, CD206, CD23
PMID:17404308
CSF1 induces IL10 and CCL2 mRNA expression in macrophages
PMID:16394015 , PMID:19667062, PMID:15067049
Fos inhibits the expression of IL-12 p40 and IFNB and upregulates IL10 production downstream of FOS in macrophages and DCs
PMID: 23986532
STING ablation abolished hallmark TGF-β and IL-10 regulatory cytokine induction (mRNA)by apoptotic cells, and proinflammatory IL-6 mRNA was expressed instead in DCs
PMID:17114424
Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals.
PMID: 25215878
FL partially antagonized IL-10-mediated inhibition on DCs function (probably via STAT3) and downregulates IL10 mRNA expression in DCs.
PMID:16713974, PMID:14607900
INFG inhibits Il-10 exspression upregulated by TLR signaling partially via STAT1. STAT1 overexpression prevents STAT3 homodimerization in macrophages.
PMID:16424049
IFNG induces INOS and IL10 expression and TGFB secretion in MDSC
IL-4 dose dependently stimulated c-Maf expression (both short and long forms) in resting monocytes.c-Maf binds to the −206/−171 region in the IL-10 promoter and upregulates IL10 expression.