Protein PTGS2 map

Identifiers
HUGO:PTGS2

Maps_Modules
MODULE:EFFECTOR_INHIBITION MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_EXPRESSION MODULE:IMMUNE_SUPPRESSION

References
 MACROPHAGE  map
CASCADE:MIF
CASCADE:TLR2_4
PMID:23390297
MIF inhitits expression of M1 markers such as TNF, IL12p40, COX2, INOS, IRF-5, MHC-II, CD11c, CD80, CD86 and MIF induces expression of M2 markers as IL10, stabilin-1, MRC-1, CD206, CD23
PMID:18633355
TAM express many pro-angiogenic and angiogenesis-modulating factors in vitro, such as VEGF, basic fibroblast growth factor (bFGF, also known as FGF2), tumour necrosis factor (TNF), interleukin 1 (IL1), chemokine (C-X-C motif) ligand 8 (CXCL8; also known as IL8), cyclooxygenase 2 (COX2, also known as PTGS2), plasminogen activator, urokinase (uPA, also known as PLAU), platelet derived growth factor beta.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PTGS2@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rPTGS2@INNATE_IMMUNE_CELL_Cytosol map → map PTGS2@INNATE_IMMUNE_CELL_Cytosol map
    2. PGE2@INNATE_IMMUNE_CELL_Cytosol map → map PTGS2@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. Arachidonic acid@INNATE_IMMUNE_CELL_Cytosol map → map PGE2@INNATE_IMMUNE_CELL_Cytosol map