Gene TLR4 map

Identifiers
HUGO:TLR4

Maps_Modules
 MACROPHAGE  map
 MDSC  map
CASCADE:MIF
MODULE:INPUT_ACTIVATORS
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
CASCADE:TLR2_4
CASCADE:IFNG

References
PMID:11964313, PMID:11672593, PMID:12032143, PMID:12811837.
INFG upregulates mRNA level and surface expression of TLR4 and TLR2.
PMID:10734131, PMID:12803886, PMID:16283355
MIF upregulates expression of TLR4 in macrothages via PU.1 (SPI1) activation via PU.1 (SPI1) activation; PU.1 (SPI1) together with IRF8 relulates TLR4 expression in myeloid cells

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gTLR4@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gTLR4@INNATE_IMMUNE_CELL_Cytosol map → map rTLR4@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: