Protein PSD4 map

Identifiers
HUGO:PSD4

Maps_Modules
MODULE:IMMUNE_STIMULATION MODULE:ANTIGEN_PRESENTATION MODULE:EFFECTOR_ACTIVATION

References
 DENDRITIC_CELL  map
PMID:21458045
PSD4 is selectively expressed in the immune system and promotes GTP loading of ARL14/ARF7.
Probably downstream of PIP5K1A.

PSD4@INNATE_IMMUNE_CELL_Cytosol

Identifiers
HUGO:STAT3

Maps_Modules
 MACROPHAGE  map

References
PMID:‭21115385, PMID:7543512
‭The binding of IL-10 to its receptor activates JAK1
Two tyrosines‭ (‬Tyr‭ ‬446‭ ‬and Tyr‭ ‬496‭) ‬of IL-10RA
are phosphorylated by the JAK1,‭ ‬to which
the transcription factor STAT3‭ ‬binds via its SH2‭ ‬domain
and in turn becomes itself phosphorylated.
PMID:10347215
Only JAK1/STAT3 pathway (but not TYK) plays role in
anti-inflammatory action of IL10 in macrophages.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PSD4@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. PSD4@INNATE_IMMUNE_CELL_Cytosol map → map PSD4@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. ARL14:​GDP@INNATE_IMMUNE_CELL_Cytosol map + GTP@INNATE_IMMUNE_CELL_Cytosol map → map ARL14:​GTP@INNATE_IMMUNE_CELL_Cytosol map + GDP@INNATE_IMMUNE_CELL_Cytosol map