Protein HLA-DM* map

Identifiers
HUGO:HLA-DMA HUGO:HLA-DMB

Maps_Modules
MODULE:IMMUNE_STIMULATION MODULE:ANTIGEN_PRESENTATION MODULE:EFFECTOR_ACTIVATION

References
 DENDRITIC_CELL  map
PMID:10716924, PMID:10611337, PMID:22138314
Dendritic cells carry functional HLA-DM on the surface, which is down-regulated upon maturation.
CLIP which blocks peptide binding until HLA-DM binds to MHC II, releasing CLIP and allowing other (antigen) peptides to bind.

Modifications:
In compartment: PHAGOSOME/ENDOSOME/LYSOSOME_Membrane
  1. HLA-DM* @PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. CLIP*:​MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map + CLIP*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map