Protein MHC_class_II* map

Identifiers
HUGO:HLA-DMA HUGO:HLA-DMB HUGO:HLA-DOA HUGO:HLA-DOB HUGO:HLA-DPA1 HUGO:HLA-DPB1 HUGO:HLA-DQA1 HUGO:HLA-DQA2 HUGO:HLA-DQB1 HUGO:HLA-DQB2 HUGO:HLA-DRA HUGO:HLA-DRB1 HUGO:HLA-DRB3 HUGO:HLA-DRB4 HUGO:HLA-DRB5

Maps_Modules
 DENDRITIC_CELL  map
 MACROPHAGE  map
MODULE:IMMUNE_STIMULATION
MODULE:ANTIGEN_PRESENTATION
MODULE:EFFECTOR_ACTIVATION
CASCADE:MIF
CASCADE:IL6
CASCADE:IL10
CASCADE:TLR2_4
CASCADE:CSF2
CASCADE:FLT3LG
CASCADE:TNF
CASCADE:IFNAB
CASCADE:IFNG

References
PMID:12391186
Maturation of monocyte-derived DCs was induced by TNF-α
The surface levels of MHC class II increased markedly after TNF-α stimulation on CD83+ DC
PMID:23390297
MIF inhitits expression of M1 markers such as TNF, IL12p40, COX2, INOS, IRF-5, MHC-II, CD11c, CD80, CD86 and MIF induces expression of M2 markers as IL10, stabilin-1, MRC-1, CD206, CD23
PMID:22076556, PMID:22076556, PMID:25720354
Like MHC class I molecules, class II molecules are also heterodimers, but in this case consist of two homogenous peptides, an α and β chain, both of which are encoded in the MHC.
MHC class II molecules present antigen peptides to CD4+ T cells
PMID:22076556, PMID:21220452
CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation.
PMID:11702064
IL15 signaling upregulates surface expression of MHC class II
PMID:16286017
cathepsin S activity was responsible for the IL-6-mediated decrease in MHCII αβ dimer, Ii, and H2-DM levels in DCs.
PMID:17513775
Probably via STAT1(demondrtated for CD40 and CD11c PMID:14764699, and for CD40, CD80, CD86, and MHC II  )

Modifications:
In compartment: Endoplasmic Reticulum_Membrane
  1. MHC_class_II*@Endoplasmic Reticulum_Membrane map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. MHC_class_II*@INNATE_IMMUNE_CELL_Cytosol map
In compartment: PHAGOSOME/ENDOSOME/LYSOSOME_Membrane
  1. MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
Participates in complexes:
In compartment: Endoplasmic Reticulum_Membrane
  1. CD74:​MHC_class_II*@Endoplasmic Reticulum_Membrane map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. MHC_class_II*|​ubi:​Tumor_antigen_fragment@INNATE_IMMUNE_CELL_Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CD74:​MHC_class_II*@INNATE_IMMUNE_CELL_Membrane map
  2. MHC_class_II*:​Tumor_antigen_fragment@INNATE_IMMUNE_CELL_Membrane map
In compartment: PHAGOSOME/ENDOSOME/LYSOSOME_Membrane
  1. CD74:​MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
  2. CLIP*:​MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
  3. MHC_class_II*:​Tumor_antigen_fragment@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
Participates in reactions:
As Reactant or Product:
  1. CD74:​MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map degraded
  2. MHC_class_II*|​ubi:​Tumor_antigen_fragment@INNATE_IMMUNE_CELL_Cytosol map → map degraded
  3. CD74:​MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map CLIP*:​MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
  4. CLIP*:​MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map + CLIP*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
  5. Tumor_antigen_fragment@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map + MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map MHC_class_II*:​Tumor_antigen_fragment@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
  6. CD74:​MHC_class_II*@Endoplasmic Reticulum_Membrane map → map CD74:​MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
  7. MHC_class_II*:​Tumor_antigen_fragment@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map MHC_class_II*:​Tumor_antigen_fragment@INNATE_IMMUNE_CELL_Membrane map
  8. MHC_class_II*:​Tumor_antigen_fragment@INNATE_IMMUNE_CELL_Membrane map → map Antigen_presentation@default map
  9. MHC_class_II*:​Tumor_antigen_fragment@INNATE_IMMUNE_CELL_Membrane map → map MHC_class_II*|​ubi:​Tumor_antigen_fragment@INNATE_IMMUNE_CELL_Cytosol map
  10. CD74:​MHC_class_II*@Endoplasmic Reticulum_Membrane map → map CD74:​MHC_class_II*@INNATE_IMMUNE_CELL_Membrane map
  11. CD74:​MHC_class_II*@INNATE_IMMUNE_CELL_Membrane map → map CD74:​MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
  12. rMHC class II*@INNATE_IMMUNE_CELL_Cytosol map → map MHC_class_II*@INNATE_IMMUNE_CELL_Cytosol map
  13. CD74@Endoplasmic Reticulum_Membrane map + MHC_class_II*@Endoplasmic Reticulum_Membrane map → map CD74:​MHC_class_II*@Endoplasmic Reticulum_Membrane map
  14. MHC_class_II*@INNATE_IMMUNE_CELL_Cytosol map → map MHC_class_II*@Endoplasmic Reticulum_Membrane map
As Catalyser: