Gene IFNB* map

Identifiers
HUGO:IFNB1

Maps_Modules
 MACROPHAGE  map
 DENDRITIC_CELL  map
MODULE:INPUT_ACTIVATORS
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
MODULE:EFFECTOR_ACTIVATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION
CASCADE:TGFB
CASCADE:STING
CASCADE:TLR2_4
CASCADE:TNF

References
PMID:18345002
TNF induced IFNB expression through IRF1. TNF-induced Ifnb1 expression was completely abrogated in IRF1-deficient macrophages.
PMID:22331441
Smad2/3 inhibited IFN-β production by suppressing IRF3 transcriptional activity.
Smad2/3 somehow suppresses IRF3 phosphorylation.
PMID:16394015 , PMID:19667062, PMID:15067049
Fos inhibits the expression of IL-12 p40 and IFNB and upregulates IL10 production downstream of FOS in macrophages and
PMID:25517615, PMID:25517609, PMID:24766893
IRF3 induces IFNB expression in DC downsteam of STING signaling
PMID:17114424, PMID: 16306937
Myeloid dendritic cells, but not plasmacytoid dendritic cells, express IL-10 and probably IFNB in response to TRIF-dependent TLR signals via TRAF3 probably downstream of HMGB1.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gIFNB*@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gIFNB*@INNATE_IMMUNE_CELL_Cytosol map → map rINFB*@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: