Phenotype apoptosis map
apoptosis@microglia
Symbol:
Name: apoptotic process
Description:
Previous Symbols:
Synonyms:
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
Modifications:
In compartment: microglia
  1. apoptosis@microglia map
In compartment: neuron
  1. apoptosis@neuron map
In compartment: nucleus
  1. apoptosis@nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. extrinsic apoptotic signalling pathway@neuron map → map apoptosis@neuron map
    2. BCL2L11|​S65_pho:​PIN1@neuron map → map apoptosis@neuron map
    3. PPIF:​SLC25A4:​VDAC1@mitochondrial matrix map → map apoptosis@neuron map
    4. MCL1@neuron map → map apoptosis@neuron map
    5. ATG12:​MCL1@neuron map → map apoptosis@neuron map
    6. BAX@mitochondrion map → map apoptosis@neuron map
    7. CYCS@neuron map → map apoptosis@neuron map
    8. BCL2L1 (fragment 25-233)@neuron map → map apoptosis@neuron map
    9. MAPK8@neuron map → map apoptosis@neuron map
    10. rBCL2L11@nucleus map → map apoptosis@nucleus map
    11. rBBC3@nucleus map → map apoptosis@nucleus map
    12. (ERN2|​hm2:​generic protein|​misfolded)|​active@ER map → map apoptosis@neuron map
    13. rFASLG@nucleus map → map apoptosis@nucleus map
    14. rTXNIP@nucleus map → map apoptosis@nucleus map
    15. rBCL2L11@nucleus map → map apoptosis@nucleus map
    16. rBBC3@nucleus map → map apoptosis@nucleus map
    17. rBID@nucleus map → map apoptosis@nucleus map
    18. rBCL2@nucleus map → map apoptosis@nucleus map
    19. apoptosis@neuron map → map neuron death@neuron map
    20. rPLXNA1@nucleus map → map apoptosis@nucleus map
    21. NRP1:​PLXNA1@microglia map → map apoptosis@microglia map
    22. rNRP1@nucleus map → map apoptosis@nucleus map
    23. extrinsic apoptotic signalling pathway@neuron map → map apoptosis@neuron map
    As Catalyser:
    1. MFN1@mitochondrion map + BAK1@neuron map → map BAK1:​MFN1@neuron map